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Development and Research of Cephalosporin Antibiotics

Yutong Wu
International Journal of Public Health and Medical Research, (2025), Vol.3, No.3, pp.61-68
Published: April 29, 2025
DOI: 10.62051/ijphmr.v3n3.07
PDF: Download Full Text PDF
Abstract

Cephalosporins are a class of broad-spectrum antibiotics. Due to their broad spectrum, high efficacy, strong antibacterial activity, and minimal side effects, they have gained significant clinical attention. With the increase in bacterial infections and the widespread use of cephalosporins, there has been an increase in bacterial resistance to cephalosporin drugs and an increase in adverse reactions. The development of new cephalosporin drugs has become a major direction. This study reviews the changes in cephalosporin synthesis routes and the historical development of cephalosporin drugs, and discusses the challenges and progress in antibiotic drug research. It aims to provide insights for developing new cephalosporin drugs that are more effective against resistant bacteria and have stronger activity.

Keywords: Antimicrobial drugs, Antibiotics, Cephalosporins
APA Citation: Yutong Wu (2025). Development and Research of Cephalosporin Antibiotics. International Journal of Public Health and Medical Research, 3(3), 61-68. https://doi.org/10.62051/ijphmr.v3n3.07

References

  1. Chen Q P. Synthesis of 7β-(6-substitution-2-quinolone-3-acetylamino) cephalosporins [J]. Acta Pharmacologica Sinica, 1989, 24(9):659-667. DOI:10.3321/j.issn:0513-4870.1989.09.002.
  2. Synthesis and Antibacterial Activity of New Cephalosporin Compounds [J]. Chinese Chemical Letters (English Edition), 2005, 16(10):1305-1308. (in Chinese)
  3. KHAN, DAVID A., BANERJI, ALEENA, BERNSTEIN, JONATHAN A., et al. Cephalosporin Allergy: Current Understanding and Future Challenges [J]. The journal of allergy and clinical immunology. In Practice. J, 2019, 7 (7): 2105 - +. DOI: 10.1016 / j.j aip. 2019.06.001.
  4. A.D. RUSSELL, P.C. TOTTLE. Lytic Activity of a New Cephalosporin, Cefuroxime, [J]. Chemotherapy, 1978, 24(6):354-359. DOI:10.1159/000237807.
  5. CHUNJING LIU, DINAH DUTTA, LESTER MITSCHER. Design and synthesis of new cephalosporin antibiotics [J]. Monatshefte fur Chemie, 2014, 145(4):633-638. DOI: 10.1007 / s00706-014-1152-6.
  6. A. D. RUSSELL, D. T. ROGERS. Antibacterial Activity of a New Cephalosporin, Cefotaxime [J]. Journal of Applied Bacteriology, 1980, 49(1):137-141. DOI:10.1111/ J.1365-2672.1980.tb01051.x.
  7. D.GREENWOOD, N. J.PEARSON, F.O'GRADY. Cefuroxime: a new cephalosporin antibiotic with enhanced stability to enterobacterialβ-lactamases [J]. Journal of Antimicrobial Chemotherapy, 1976, 2 (4): 337-343.
  8. E. P. ABRAHAM. The cephalosporin C group [J]. Quarterly Reviews, Chemical Society, 1967, 21 (2): 231-248. The DOI: 10.1039 / QR9672100231.
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